94813-61-3Relevant academic research and scientific papers
Preparation method D- proline derivative and intermediate thereof (by machine translation)
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Paragraph 0044-0047; 0052-0054; 0059-0061, (2020/05/01)
The invention discloses a preparation method D - of, methyl - D D-proline hydrochloride (R)- 1 -methyl pyrrolidine - 2 2-yl :1) acrylic acid, which is prepared by reacting 1 - methyl-D-proline hydrochloride with hydrogen gas to prepare 1 - methyl - D D- hollylchloride, and then carrying out catalytic hydrogenation reaction, with hydrogen to prepare an intermediate ;D - proline derivative (R,E) - 3 - (1 - methyl pyrrolidine - 2 2- yl) acrylic acid and a preparation method, of the intermediate (R)- 1 -methyl, pyrrolidine-2-formylphenyl acrylic acid, and a preparation method of the intermediate thereof can, be prepared (R,E) - 3 - (1 - by catalyzing and hydrogenating), methylpyrroli- 2 2- glyoxylic acid. The present invention relates to a method for preparing the intermediate. beta. (by machine translation)
