94815-31-3

Upstream product

• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 917-64-6 methyl magnesium iodide 
• 925940-91-6 5-(3-Iodophenyl)isoxazole-3-carbaldehyde 

Downstream Products

• 86905-46-6 2-Methyl-5-phenyl-furan-3-one 
• 38053-08-6 2-methyl-5-phenyl-3(2H)-furanone 
• 925940-93-8 3-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-(3-iodo-phenyl)-isoxazole 
• 95013-69-7 2-penten-1-one-3-amino-4-hydroxy-1-phenyl 

Relevant academic research and scientific papers

ETHYL 5-SUBSTITUTED-3-ISOXAZOLECARBOXYLATES AS STARTING MATERIALS FOR A CONVENIENT ROUTE TO 3(2H)FURANONES AND 3(2H)IMINOFURANES.

Cyclodehydration of γ-hydroxy-β-enaminoketones derived from 5-substituted-3-isoxazolemethanols leads to 3(2H)furanones or 3(2H)iminofuranes depending on the substitution pattern and on the reaction conditions.

Substituted piperazines as metabotropic glutamate receptor antagonists

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

MGluR5 modulators VI

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.