948304-34-5Relevant academic research and scientific papers
SORAFENIB DERIVATIVES AS sEH INHIBITORS
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Page/Page column 42, (2012/09/10)
The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.
Orally bioavailable potent soluble epoxide hydrolase inhibitors
Sung, Hee Hwang,Tsai, Hsing-Ju,Liu, Jun-Yan,Morisseau, Christophe,Hammock, Bruce D.
, p. 3825 - 3840 (2008/02/13)
A series of N,N′-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane α to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activi
