948575-58-4

Usage

Uses

Used in Pharmaceutical Industry:
4-hydroxy-2-sulfanylpyrazolo[1,5-a][1,3,5]triazine-8-carbonitrile is used as a potential pharmaceutical agent for its unique structure and properties. The presence of the hydroxy and sulfur groups allows for potential interactions with biological systems, which may contribute to its therapeutic effects. Additionally, the carbonitrile group may provide specific chemical reactivity that could be harnessed for medicinal purposes.
Further research is necessary to understand the full extent of its properties and applications, as its potential in the pharmaceutical industry is currently being explored.

Upstream product

• 127981-96-8 ethyl ((4-cyano-1H-pyrazol-5-yl)carbamothioyl)carbamate 

Downstream Products

• 948575-61-9 C₁₃H₉N₅SO 

Relevant academic research and scientific papers

CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, R3, Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2

The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with μM-le