948587-87-9Relevant academic research and scientific papers
METHOD OF DEUTERIZING BENZYL-POSITION IN -O-BENZYL GROUP
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Page/Page column 16-17, (2008/12/09)
(PROBLEM) To provide a method for efficiently and industrially deuterating the benzyl position of a -O-benzyl group formed by introducing a benzyl group, a benzyloxymethyl group and the like as a protecting group. (SOLUTION) The deuteration method for the benzyl position of a -O-benzyl group of a compound having the -O-benzyl group which may have a substituent, comprising reacting the compound with a heavy hydrogen source in the coexistence of a palladium/carbon-ethylenediamine complex and hydrogen.
