94867-39-7Relevant academic research and scientific papers
Preparation of aminals in water
Jur?ík, Václav,Wilhelm, René
, p. 3205 - 3210 (2007/10/03)
Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal.
Synthesis and evaluation of antiinflammatory and analgesic activity of some new 1,3-diphenyl-2-aryltetrahydroimidazoles
Khan,Gupta, Monica
, p. 2086 - 2090 (2007/10/03)
In an effort to search for new antiinflammatory and analgesic agents, some new tetrahydroimidazole derivatives 2a-2g have been synthesized via condensation of 1,2-dianilinoethane with various aldehydes. Characterization of the newly synthesized compounds has been done on the basis of 1H NMR and mass spectral data. The resulting compounds have been evaluated for their antiinflammatory activity. The activity of compounds 2b and 2c is excellent and comparable to indomethacin. All these compounds have been tested for their analgesic activity also and their LD50 determined. Compounds 2b and 2c show a comparable activity with aspirin. The MTD for all the compounds is found to be >1800 mg/kg.
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, a Mild Catalyst for the Formation of Carbon-Nitrogen Bonds
Eynde, Jean Jacques Vanden,Delfosse, Florence,Lor, Pascal,Haverbeke, Yves Van
, p. 5813 - 5818 (2007/10/02)
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) catalyzes the preparation of N-tetrahydropyranylbenzazoles, 2-substituted 1,3-diphenylimidazolidines, and N-(arylmethylene)benzene-1,2-diamines.In the latter case, use of one equivalent of DDQ provides a novel one-pot method for the synthesis of 1H-benzimidazoles.
BENTONITE K10 CLAY, AN EFFICIENT CATALYST FOR THE FORMATION OF NITROGEN DERIVATIVES
Eynde, Jean Jacques Vanden,Mayence, Annie,Lor, Pascal,Haverbeke, Yves Van
, p. 387 - 392 (2007/10/02)
Bentonite K10 clay has been used to catalyze the formation of enamino carbonyl derivatives, 2-methyl-1H-benzimidazoles, Hantzsch 1,4-dihydropyridines, Hantzsch pyridines, 2-substituted 1,3-diphenylimidazolidines, and tetrahydropyranylbenzazoles.
NOVEL SYNTHESES OF HETEROCYCLES WITH N-(1-HALOALKYL)AZINIUM HALIDES PART 1. PREPARATION OF IMIDAZOLIDINES
Eynde, J.-J. Vanden,Mayence, A.,Maquestiau, A.,Anders, E.
, p. 233 - 236 (2007/10/02)
N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and an aldehyde, readily react with N,N'-disubstituted 1,2-ethanediamine to yield imidazolidines under mild and neutral conditions.
