948859-37-8Relevant articles and documents
Testing phosphanes in the palladium-catalysed allylation of secondary and primary amines
Thoumazet, Claire,Gruetzmacher, Hansjoerg,Deschamps, Bernard,Ricard, Louis,Le Floch, Pascal
, p. 3911 - 3922 (2007/10/03)
The electronic nature of the ligand plays a crucial role in the palladium-catalysed allylation of amines with allylic alcohols. The better the ligand is as a π acceptor, the more active the catalyst. Experiments with a series with mono- and bidentate ligands featuring phosphanes and phospholes applied in the catalytic allylation of aniline clearly demonstrate this. Bolstered by DFT calculations, we have devised a new efficient catalyst for this process which carries the strong π acceptor 1,2,5-triphenylphosphole as a ligand. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.