948859-96-9

Usage

Uses

Used in Organic Synthesis:
6-BROMO-2-NAPHTHOHYDRAZIDE is used as a reagent for [facilitating the synthesis of complex organic molecules] because of its unique chemical structure and reactivity.
Used in Pharmaceutical Production:
6-BROMO-2-NAPHTHOHYDRAZIDE is used as an intermediate for [the synthesis of various pharmaceuticals] due to its role in the formation of active pharmaceutical ingredients.
Used in Agrochemical Production:
6-BROMO-2-NAPHTHOHYDRAZIDE is used as an intermediate for [the development of agrochemicals] because of its potential to contribute to the creation of effective crop protection agents.
Used in Antimicrobial Applications:
6-BROMO-2-NAPHTHOHYDRAZIDE is used as an antimicrobial agent for [inhibiting the growth of microorganisms] due to its inherent antimicrobial properties.
Used in Tuberculosis Treatment Research:
6-BROMO-2-NAPHTHOHYDRAZIDE is used as a potential therapeutic agent for [treatment of tuberculosis] because of its inhibitory activity against the mycobacterium tuberculosis enzyme, Pks13.
Used in Heterocyclic Compound Synthesis:
6-BROMO-2-NAPHTHOHYDRAZIDE is used as a building block for [the synthesis of heterocyclic compounds] due to its ability to form diverse ring systems with potential applications in various fields.

Upstream product

• 33626-98-1 methyl 6-bromo-2-naphthoate 
• 86471-14-9 ethyl 6-bromo-naphthalene-2-carboxylate 

Downstream Products

• 1147840-51-4 6-bromo-naphthalene-2-carboxylic acid (3,5-dibromo-2,4-dihydroxy-benzylidene)-hydrazide 
• 1421511-88-7 6-bromo-N'-(3,5-dibromo-4-hydroxy-2-methoxybenzylidene)-2-naphthohydrazide 
• 1421511-87-6 6-bromo-N'-(3,5-dibromo-2-hydroxy-4-methoxybenzylidene)-2-naphthohydrazide 
• 948859-97-0 C₁₈H₁₃BrN₂O₂ 

Relevant academic research and scientific papers

Preparation, thermal analyses and biological activities of Co(II) and Cr(III) complexes with 2-acetylpyridine-6-bromo-2-naphthoyl acylhydrazone

Novel six-coordinated octahedral Co(II) complex [C36H26Br2CoN7O5, 1] and Cr(III) complex [C36H26Br2CrN6O2, 2] were prepared by the chelation reac

Naphthalene-ring have single crystal structure of the metal complex of the hydrazone synthetic method and application (by machine translation)

The present invention relates to naphthalene-ring hydrazone metal complex synthetic method and application, the naphthalene ring-containing hydrazone metal complexes of the structural formula is: In the formula: M is Cr or Co, the naphthalene ring-contai

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate

SIRT1 is an NAD+-dependent deacetylase, whose activators have potential therapeutic applications in age-related diseases. Here we report a new class of SIRT1 activators. The activation is dependent on the fluorophore labeled to the substrate. To elucidate the activation mechanism, we solved the crystal structure of SIRT3/ac-RHKKac-AMC complex. The structure revealed that the fluorophore blocked the H-bond formation and created a cavity between the substrate and the Rossmann fold. We built the SIRT1/ac-RHKK ac-AMC complex model based on the crystal structure. Km and Kd determinations demonstrated that the fluorophore decreased the peptide binding affinity. The binding modes of SIRT1 activators indicated that a portion of the activators interacts with the fluorophore through π-stacking, while the other portion inserts into the cavity or interacts with the Rossmann fold, thus increasing the substrate affinity. Our study provides new insights into the mechanism of SIRT1 activation and may aid the design of novel SIRT1 activators.

Discovering potent inhibitors against the β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of helicobacter pylori: Structure-based design, synthesis, bioassay, and crystal structure determination

The discovery of HpFabZ inhibitors is now of special interest in the treatment of various gastric diseases. In this work, three series of derivatives (compounds 3, 4, and 5) were designed, synthesized, and their biological activities were investigated as potential HpFabZ inhibitors in a two phased manner. First, we designed and synthesized two series of derivatives (3a-r and 4a-u) and evaluated the enzyme-based assay against HpFabZ. Five compounds (3i-k, 3m, and 3q) showed potential inhibitory activity, with IC50 values less than 2 μM. Second, a focused combinatorial library containing 280 molecules was designed employing the LD1.0 program. Twelve compounds (5a-l) were selected and synthesized. The activity of the most potent compound 5h (IC 50) 0.86 μM) was 46 times higher than that of the hit 1. The high hit rate and the potency of the new HpFabZ inhibitors demonstrated the efficiency of the strategy for the focused library design and virtual screening.

NOVEL ANTHRACENE DERIVATIVE AND ORGANIC ELECTRONIC DEVICE USING THE SAME

The present invention provides a novel anthracene derivative and an organic electronic device using the same. The organic electronic device according to the present invention shows excellent characteristics in efficiency, drive voltage, and life time.