948859-96-9

Basic information

• Product Name: 6-BROMO-2-NAPHTHOHYDRAZIDE
• Synonyms: 6-bromonaphthalene-2-carbohydrazide;6-Bromo-2-naphthalenecarboxylic acid hydrazide;2-Naphthalenecarboxylic acid, 6-bromo-, hydrazide
• CAS NO: 948859-96-9
• Molecular Formula: C₁₁H₉BrN₂O
• Molecular Weight: 265.11
• Mol File: 948859-96-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-BROMO-2-NAPHTHOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-NAPHTHOHYDRAZIDE(948859-96-9)
• EPA Substance Registry System: 6-BROMO-2-NAPHTHOHYDRAZIDE(948859-96-9)

Safety Data

• Hazardous Substances Data: 948859-96-9(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-naphthohydrazide is a chemical compound with the molecular formula C11H8BrN3O. It is a yellow to orange crystalline solid which is primarily used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. 6-BROMO-2-NAPHTHOHYDRAZIDE has been found to have antimicrobial properties and is also used in the synthesis of various heterocyclic compounds. Additionally, 6-Bromo-2-naphthohydrazide has been studied for its potential use in the treatment of tuberculosis, as it exhibits inhibitory activity against the mycobacterium tuberculosis enzyme, Pks13. Overall, this chemical has several potential industrial and pharmaceutical applications and is a valuable tool for researchers in the field of organic synthesis and drug discovery.

Upstream product

• 86471-14-9 ethyl 6-bromo-naphthalene-2-carboxylate 
• 33626-98-1 methyl 6-bromo-2-naphthoate 

Downstream Products

• 1147840-51-4 6-bromo-naphthalene-2-carboxylic acid (3,5-dibromo-2,4-dihydroxy-benzylidene)-hydrazide 
• 1421511-88-7 6-bromo-N'-(3,5-dibromo-4-hydroxy-2-methoxybenzylidene)-2-naphthohydrazide 
• 1421511-87-6 6-bromo-N'-(3,5-dibromo-2-hydroxy-4-methoxybenzylidene)-2-naphthohydrazide 
• 948859-97-0 C₁₈H₁₃BrN₂O₂ 

Relevant articles and documents

Preparation, thermal analyses and biological activities of Co(II) and Cr(III) complexes with 2-acetylpyridine-6-bromo-2-naphthoyl acylhydrazone

Novel six-coordinated octahedral Co(II) complex [C36H26Br2CoN7O5, 1] and Cr(III) complex [C36H26Br2CrN6O2, 2] were prepared by the chelation reac

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate

SIRT1 is an NAD+-dependent deacetylase, whose activators have potential therapeutic applications in age-related diseases. Here we report a new class of SIRT1 activators. The activation is dependent on the fluorophore labeled to the substrate. To elucidate the activation mechanism, we solved the crystal structure of SIRT3/ac-RHKKac-AMC complex. The structure revealed that the fluorophore blocked the H-bond formation and created a cavity between the substrate and the Rossmann fold. We built the SIRT1/ac-RHKK ac-AMC complex model based on the crystal structure. Km and Kd determinations demonstrated that the fluorophore decreased the peptide binding affinity. The binding modes of SIRT1 activators indicated that a portion of the activators interacts with the fluorophore through π-stacking, while the other portion inserts into the cavity or interacts with the Rossmann fold, thus increasing the substrate affinity. Our study provides new insights into the mechanism of SIRT1 activation and may aid the design of novel SIRT1 activators.

NOVEL ANTHRACENE DERIVATIVE AND ORGANIC ELECTRONIC DEVICE USING THE SAME

The present invention provides a novel anthracene derivative and an organic electronic device using the same. The organic electronic device according to the present invention shows excellent characteristics in efficiency, drive voltage, and life time.