94887-76-0Relevant articles and documents
Copper(II) complex with the tridentate ligand N,N-bis(2-ethyl-4-methyl- imidazol-5-ylmethyl)phenylethylamine (biaq). X-ray crystal structure and biological activity on bacillus subtilis of [Cu(biaq)Cl2].
Mendoza, Angeles,Mendoza-Diaz, Guillermo,Pedraza-Reyes, Mario,Bernes, Sylvain
, p. 1455 - 1460 (2013/08/23)
The ligand N,N-bis(2-ethyl-4-methyl-imidazol-5-ylmethyl)-1-phenylethylamine (biaq) was prepared by Mannich reaction of 2-ethyl-4-methyl-1H-imidazole, (R)-1-phenylethylamine and formaldehyde. It was characterized by FTIR and NMR spectroscopy. This ligand reacts with CuCl2 to give a coordination compound with formula [Cu(biaq)Cl2]. In this compound, biaq acts as a tridentate ligand with one tertiary amine and two azole nitrogen atoms coordinated to the central metal atom. The complex was characterized by FTIR spectroscopy, elemental analysis, and X-ray diffraction. The X-ray structure of [Cu(biaq)Cl2] shows a pentacoordinate cooper(II) atom, where two chloride ions and the three nitrogen atoms of the biaq ligand are coordinated in a distorted square pyramidal arrangement. The biological activity of the complex [Cu(biaq)Cl2] was tested using the Gram positive bacterium Bacillus subtilis as a model. Results revealed that the copper complex interfered with bacterial growth, inducing cell death, most probably by altering the primary structure of the chromosome, since a significant increase of the mutation frequency to rifampicin resistance was observed. Copyright
Process for producing 1-hydroxymethylimidazoles
-
, (2008/06/13)
1-Hydroxymethylimidazoles which are unsubstituted or alkyl-substituted in the 2-position, their manufacture and their use as chemical intermediates, e.g. for other imidazole derivatives or for the drug cimetidine.
