948892-68-0Relevant academic research and scientific papers
Dimethylformamide dimethyl acetal in heterocyclic synthesis: Synthesis of polyfunctionally substituted pyridine derivatives as precursors to bicycles and polycycles [1,2]
Abu-Shanab, Fathi A.,Hessen,Mousa
, p. 787 - 791 (2008/03/29)
(Chemical Equation Presented) Polysubstituted pyridines 11a,c and 12 were prepared by the reaction of benzoylacetone with dimethylformamide dimethyl acetal followed by treatment with cyanothioacetamide 9a, cyanoacetamide 9b and the anion of malononitrile dimmer 9c in dry DMF. When the reaction was carried out in ethanol as a solvent and piperidine as a base afforded 14a,b. Thienopyridines 16a,b were prepared by the reaction of pyridinethiones 11a and 14a with 2-chloro-N-p-tolyl-acetamide (15). Further reaction of thienopyridines 16a,b with either DMFDMA or nitrous acid to gave 17a,b and 18a,b respectively. The reaction of pyridine derivative 11c with hydrazine and phenylhydrazine afforded the tricyclic compounds 19a,b.
Synthesis of 1-(β-D-glycopyranosyl)-3-deazapyrimidines from 2-hydroxy and 2-mercaptopyridines
Attia, Adel M.,Elgemeie, Galal H.,Alnaimi, Ibrahim S.
, p. 1355 - 1363 (2007/10/03)
The synthesis of new 4- and 5-substituted-3-cyanopyridine nucleosides has been performed by reacting the silylated pyridines and penta-O-aeetyl-α -Dglycopyranose in dichloroethane in the presence of SnCl4. The free nucleosides were tested for their potential activity against HIV and different types of tumor.
