949008-25-7Relevant academic research and scientific papers
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors
Powell, Noel A.,Ciske, Fred L.,Cai, Cuiman,Holsworth, Daniel D.,Mennen, Ken,Van Huis, Chad A.,Jalaie, Mehran,Day, Jacqueline,Mastronardi, Michelle,McConnell, Pat,Mochalkin, Igor,Zhang, Erli,Ryan, Michael J.,Bryant, John,Collard, Wendy,Ferreira, Suzie,Gu, Chungang,Collins, Roxane,Edmunds, Jeremy J.
, p. 5912 - 5949 (2007)
We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitution pattern exhibit potent renin inhibition and good pe
