949034-45-1

Usage

Uses

Used in Pharmaceutical Industry:
CHEMBRDG-BB 4005123 is used as an intermediate in the synthesis of pharmaceuticals for its ability to participate in various chemical reactions and its potential medicinal properties.
Used in Drug Development:
CHEMBRDG-BB 4005123 is used as a building block for the development of new pharmaceutical compounds with therapeutic applications.

InChI:InChI=1/C6H6N2O3/c1-3(9)4-2-5(6(10)11)8-7-4/h2H,1H3,(H,7,8)(H,10,11)

Upstream product

• 40753-41-1 5-(1-methyl-2-phenyl-vinyl)-1⁽²⁾H-pyrazole-3-carboxylic acid 
• 623-73-4 diazoacetic acid ethyl ester 
• 1423-60-5 methyl ethynyl ketone 
• 37622-89-2 5-acetyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 3112-31-0 3,5-pyrazoledicarboxylic acid 
• 1403332-85-3 5-acetyl-N-(2,6-diethylphenyl)-1H-pyrazole-3-carboxamide 
• 1297537-33-7 5-acetyl-N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-1H-pyrazole-3-carboxamide 
• 1297538-32-9 N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide 
• 1562404-69-6 (2S,4R)-4-[(5-acetyl-1H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-ethoxymethyl-2-methylpentanoic acid 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZOLE COMPOUNDS, COMPOSITIONS CONTAINING SAME, AND USE THEREOF

The present invention provides substituted pyrazole compounds, compositions containing same, and use thereof. The substituted pyrazole compounds comprise a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate, or solvate thereof. The compound represented by formula (I) can serve as a tissue selective androgen receptor modulator (SARM), particularly serving as a drug for treating prostate cancer and other AR-dependent conditions and diseases in which AR antagonism is desired.

Pyrazoleamide derivative and synthesis method and application

The present invention discloses a pyrazoleamide derivative and a synthetic method and application as an androgen receptor antagonist and the preparation of anti-prostate cancer drugs. The present invention provides a method of synthesizing a pentabasole r

Compound and process for synthesizing 5-acetyl-1H-pyrazole-3-carboxylic acid by using compound

The invention belongs to the field of chemical synthesis of substances and discloses a compound, application and a process for synthesizing 5-acetyl-1H-pyrazole-3-carboxylic acid by using the compound. A compound 2, 3-butanedione is used as a starting material to synthesize a compound intermediate III, the compound intermediate III is separated out from the system, the product conversion is promoted, the purification purpose can be achieved through filtration, the conversion rate reaches 95%, and the yield is increased; synthesis of an intermediate IV: by taking the intermediate III and a hydrazine compound as raw materials, the pH of the system is regulated, the yield is increased, and impurity production is reduced; after the reaction is ended, concentrating and filtering are carried out, so that the yield reaches 98%, and the HPLC purity is greater than 98.5%; and through the operation, high-purity V is obtained. The process of the invention is simple and safe, high in yield, suitable for industrialization, beneficial to impurity control and capable of reducing quality risks.

PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.