949086-97-9

Upstream product

• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 949086-96-8 2,2'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis-[1H-isoindole-1,3(2H)-dione] 
• 188125-86-2 1,3-dichloropropan-2-one O-benzyloxime 

Downstream Products

• 949087-01-8 (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]carboxamide} 
• 949087-11-0 (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanamide] 
• 949087-12-1 (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide] 
• 949087-06-3 N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis[(2R)-3-(benzyloxy)-2-hydroxypropanamide] 
• 949087-05-2 N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-2,3-dihydroxypropanamide] 

Relevant academic research and scientific papers

Synthetic studies towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes: access to 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one and 2H-1,4-oxazin-3(4H)-one frameworks

Synthetic approaches towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes starting from 1,3-dichloroacetone and solketal derivatives are explored. The method relies on the preparation of a key bis-substituted dihydroxy-protected oxime, which would undergo a final acidic deprotection-spiroacetalization process. Although the desired diazaspiroketal framework could not be obtained, our conditions led to the unexpected 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one 18 or to the oxazinone 32 in good yields.

Synthesis, and In Vitro and In Vivo Muscarinic Pharmacological Properties of a Series of 1,6-Dihydro-5(4H)-pyrimidinone Oximes

A series of 1,6-dihydro-5-(4H)-pyrimidinone oxime derivatives I was synthesized (Scheme 1, Tables 1 and 2) and tested for muscarinic activity (Table 3) in receptor binding assays using -oxotremorine-M (Oxo-M) and -pirenzepine (Pz) as ligands.Poten