949093-98-5

Upstream product

• 214280-56-5 (+)-(1R,4R)-1,4-diphenylbutane-1,4-diol 
• 495-71-6 phenacylacetophenone 
• 295328-90-4 (1R,4R)-1,4-bis(methanesulfonyloxy)-1,4-diphenylbutane 

Downstream Products

• 882353-88-0 (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane 

Relevant academic research and scientific papers

P-aryl-diphenylphospholanes and their phospholanium salts as efficient monodentate ligands for asymmetric rhodium-catalyzed hydrogenation

Enantiopure P-aryl-2,5-diphenylphospholanes and its corresponding P-aryl-phospholanium salt appear as very efficient ligands for rhodium-catalyzed asymmetric hydrogenation reaction with similar activities and enantioselectivities. The hydrogenation product was obtained in good enantiomeric excesses (up to 93% ee ) in only few minutes under an atmospheric pressure of dihydrogen. The excellent activity of the catalyst can be explained by a constant and high TOF value during the reaction.

Olefination of ketenes for the enantioselective synthesis of allenes via an ylide route

Pseudo-C2-symmetric chiral phosphorus ylide is designed and synthesized for the enantioselective preparation of allenic esters, amides, ketone, and nitrile. Up to 92% ee is achieved.