949096-72-4

Basic information

• Product Name: 4-(3-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(3-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 949096-72-4
• Molecular Weight: 360.497
• Mol File: 949096-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester(949096-72-4)
• EPA Substance Registry System: 4-(3-isobutyrylamino-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester(949096-72-4)

Safety Data

• Hazardous Substances Data: 949096-72-4(Hazardous Substances Data)

Upstream product

• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 172681-47-9 3-iodo-2-methylphenylamine 
• 949096-69-9 N-(3-iodo-2-methylphenyl)isobutyramide 
• 949096-70-2 4-(3-isobutyrylamino-2-methylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 762297-43-8 N-(2-methyl-3-piperidin-4-ylphenyl)isobutyramide 
• 949096-77-9 N-(3-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-2-methylphenyl)isobutyramide 
• 762298-47-5 N-{3-[1-(3-aminopropyl)piperidin-4-yl]-2-methylphenyl}isobutyramide 

Relevant articles and documents

Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit

Melanin-concentrating hormone (MCH) is involved in the regulation of feeding, water balance, energy metabolism, general arousal and attention state, memory, cognitive functions, and psychiatric disorders. Herein, two new chemical series exemplified by N-[5-(1-{3-[2,2-bis-(4-fluoro-phenyl)-acetylamino]- propyl}-piperidin-4-yl)-2,4-difluoro-phenyl]-isobutyramide (SNAP 102739, 5m) and N-[3-(1-{3-[(S)-2-(4-fluorophenyl)-propionylamino]-propyl}-piperidin-4-yl)-4- methylphenyl]-isobutyramide ((S)-6b) are reported. These compounds were designed to improve the pharmacokinetic properties of the high-throughput screening lead compound 1 (SNAP 7941). The MCH1 receptor antagonists 5m and (S)-6b show reasonable pharmacokinetic profiles (rat bioavailability = 48 and 81%, respectively). Compounds 5m and (S)-6b demonstrated the inhibition of a centrally administered MCH-evoked drinking effect, and compound 5m exhibited oral in vivo efficacy in the rat social interaction model of anxiety, with a minimum effective dose = 0.3 mg/kg.