949152-19-6

Upstream product

• 946001-84-9 (R)-5-bromo-2-[3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridine 
• 949152-13-0 (rac)-3-{[2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylcarbamoyl}-4-oxopiperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 949152-09-4 (3'S,4'R)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide 
• 949152-23-2 (3'R,4'S)-6-[(R)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl]-4'-hydroxy-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxyethyl)benzyl]cyclopropylamide 

Relevant academic research and scientific papers

Piperidine-based renin inhibitors: Upper chain optimization

The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor wi