949156-50-7Relevant academic research and scientific papers
Coordination to copper(II) strongly enhances the in vitro antimicrobial activity of pyridine-derived N(4)-tolyl thiosemicarbazones
Mendes, Isolda C.,Moreira, Juliana P.,Mangrich, Antonio S.,Balena, Solange P.,Rodrigues, Bernardo L.,Beraldo, Heloisa
, p. 3263 - 3270 (2007)
Five copper(II) complexes with N(4)-ortho, N(4)-meta and N(4)-para-tolyl thiosemicarbazones derived from 2-formyl and 2-acetylpyridine were obtained and thoroughly characterized. The crystal structure of N(4)-meta-tolyl-2-acetylpyridine thiosemicarbazone (H2Ac4mT) was determined, as well as that of its copper(II) complex [Cu(2Ac4mT)Cl], which contains an anionic ligand and a chloride in the coordination sphere of the metal. The in vitro antimicrobial activities of all thiosemicarbazones and their copper(II) complexes were tested against Salmonella typhimurium and Candida albicans. Upon coordination a substantial decrease in the minimum inhibitory concentration, from 225 to 1478 μmol L-1 for the thiosemicarbazones to 5-30 μmol L-1 for the complexes was observe against the growth of Salmonella typhimurium and from 0.7-26 to 0.3-7 μmol L-1 against the growth of C. albicans, suggesting that complexation to copper(II) could be an interesting strategy of dose reduction.
