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Metalation of pyrazinethiocarboxamides metalation of diazines XXVI
Fruit, Corinne,Turck, Alain,Plé, Nelly,Quéguiner, Guy
, p. 2349 - 2365 (2007/10/03)
Some new pyrazinethiocarboxamides were synthesized and metalated with LTMP in tetrahydrofuran. The reaction of these lithio derivatives with various electrophiles gave access to a large range of 2,5-disubstituted pyrazines. This unexpected regioselectivit
