949415-53-6Relevant academic research and scientific papers
3-Formylchromones, acylpyruvates, and chalcone as valuable substrates for the syntheses of fused pyridines
Iaroshenko, Viktor O.,Mkrtchyan, Satenik,Volochnyuk, Dmitriy M.,Langer, Peter,Sosnovskikh, Vyacheslav Ya.,Ostrovskyi, Dmytro,Dudkin, Sergii,Kotljarov, Anton V.,Miliutina, Mariia,Savych, Iryna,Tolmachev, Andrei A.
experimental part, p. 2749 - 2758 (2010/10/21)
The reaction of electron-rich aminoheterocycles with 1,3-CCC- dielectrophiles, such as 3-formylchromones, acylpyruvates, and chalcone, provided diversely fused pyridines. Starting from 5-amino-1-(2,3-O- isopropylidene - d-ribofuranosyl)-1H-pyrazole, nucleosides containing a pyrazolo[3,4-b]pyridine fragment were obtained, which can be considered as adenosine deaminase (ADA) inhibitors. Georg Thieme Verlag Stuttgart.
