949485-81-8

Basic information

• Product Name: 5-(chlorosulfonyl)-2-fluorobenzoyl chloride
• Synonyms: 5-(chlorosulfonyl)-2-fluorobenzoyl chloride
• CAS NO: 949485-81-8
• Molecular Weight: 257.069
• Mol File: 949485-81-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-(chlorosulfonyl)-2-fluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(chlorosulfonyl)-2-fluorobenzoyl chloride(949485-81-8)
• EPA Substance Registry System: 5-(chlorosulfonyl)-2-fluorobenzoyl chloride(949485-81-8)

Safety Data

• Hazardous Substances Data: 949485-81-8(Hazardous Substances Data)

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 37098-75-2 2-fluoro-5-chlorosulfonylbenzoic acid 

Downstream Products

• 1445796-47-3 C₁₈H₁₉FN₂O₄S 
• 1445796-48-4 C₂₀H₂₁FN₂O₅S 
• 1445796-49-5 C₂₀H₂₀ClFN₂O₄S 
• 1445796-50-8 C₂₀H₂₂FN₃O₅S 
• 1445796-51-9 C₂₀H₂₁N₃O₅S 
• 1445789-31-0 C₁₈H₁₆F₄N₂O₄S 
• 1445796-55-3 3-(3,4,5-trifluorophenylcarbamoyl)-4-fluorobenzene-1-sulfonyl chloride 
• 1572510-80-5 (S)-5-(N-(sec-butyl)sulfamoyl)-N-(3,4-difluorophenyl)-2-fluorobenzamide 

Relevant articles and documents

2-Halobenzoyl chlorides in the synthesis of [1,3,4]thiadiazolo[3,2-a]quinazolin-5-one derivatives

New nitro and sulfonamide derivatives of [1,3,4]thiadiazolo[3,2-a]quinazolin-5-one have been synthesized by cyclocondensation of 1,3,4-thiadiazol-2-amines with 2-halobenzoyl chlorides containing electron-withdrawing substituents in positions 3, 4, and 5. An improved procedure has been proposed for the preparation of intermediate 2-fluoro-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamides containing a sulfamoyl group in the 5-position via selective acylation of 5-methyl-1,3,4-thiadiazol-2-amine with 5-chlorosulfonyl-2-fluorobenzoyl chloride, followed by sulfonylation of amines.

Synthesis of new sulfonamide derivatives of thiazolo[3,2-a]quinazolin-5-one

A general procedure has been proposed for the synthesis of thiazolo[3,2-a]quinazolin-5-one derivatives containing a sulfonamide group on C7via intramolecular nucleophilic substitution of halogen in 2-halo-5-sulfamoyl-N-(1,3-thiazol-2-yl)benzami

SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.