949490-29-3Relevant academic research and scientific papers
5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4
Vitale, Gabriella,Corona, Paola,Loriga, Mario,Carta, Antonio,Paglietti, Giuseppe,Giliberti, Gabriele,Sanna, Giuseppina,Farci, Pamela,Marongiu, Maria Elena,La Colla, Paolo
, p. 83 - 97 (2012)
Within a project aimed at discovering new Flaviviridae inhibitors, new variously substituted 2-phenylbenzimidazoles were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against viruses representatives of the three genera of the Flaviviridae family, i.e.: Pestivirus (BVDV), Flavivirus (YFV) and Hepacivirus (HCV). Title compounds were also tested against RNA viruses representative of other single-stranded, positive-sense (ssRNA+) negative-sense (RNA-), or double-stranded (dsRNA) genomes, as well as against representatives of two DNA virus families. Nine compounds showed activity against BVDV (EC50 = 0.8-8.0 μM), compound 31 being the most potent (EC50 = 0.80 μM) and selective (SI = CC50/EC50 = >100). When tested in an HCV replicon assay, compound 31 resulted again the most potent, displaying an EC50 value of 1.11 μM and an SI of 100. Besides inhibiting BVDV, two compounds (35 and 38) showed a moderate activity also against YFV (EC 50 = 13 μM). Interestingly, 35 was moderately active also against RSV (EC50 = 25 μM).
Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water
Bailey, J. Daniel,Iyer, Karthik S.,Leahy, David K.,Li, Xiaohan,Lipshutz, Bruce H.,Thakore, Ruchita R.
supporting information, p. 7205 - 7208 (2021/09/22)
Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.
