949586-52-1Relevant academic research and scientific papers
Asymmetric α-hydroxy ketone synthesis by direct ketone oxidation using a bimetallic palladium(II) complex
Hamed, Othman A.,El-Qisairi, Arab,Qaseer, Hanan,Hamed, Emad M.,Henry, Patrick M.,Becker, Daniel P.
, p. 2699 - 2701 (2012)
The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF-water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee's ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.
