949588-40-3 Usage
Enzyme inhibitor
This synthetic drug (FW = 339.43 g/mol; CAS 949588-40-3), known systematically as 2-([(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen- 2-yl]methylmethylamino)acetate, is a selective inhibitor of the sodium/chloride-dependent glycine transporter GlyT1, counteracting the effects of the dissociative drug ketamine. Rationale: Elevation of extracellular synaptic concentration of glycine by blockade of GlyT1 is believed to potentiate NMDA receptor function in vivo, thereby suggesting a rational approach for the treatment of schizophrenia and cognitive disorders. Moreover, accumbal glycine receptors (GlyRs) are involved in mediating the dopamine activating effects of ethanol, and that administration of glycine locally into the nucleus accumbens (nAc) reduces ethanol consumption in ethanol high-preferring rats. Org-25935 decreased ethanol intake and ethanol preference, as compared with vehicle, whereas water intake was unaffected. This effect was dose-dependent, developed gradually and was sustained for up to 40 days Note: Other GlyT1 inhibitors include GSK931145, Lu AA21279, NFPS, Org 25935, SB-710622, SSR 504734, whereas D-serine is an agonist. All GlyT1 inhibitors increased seizure thresholds dose-dependently, indicative of anticonvulsant activity.
Check Digit Verification of cas no
The CAS Registry Mumber 949588-40-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,9,5,8 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 949588-40:
(8*9)+(7*4)+(6*9)+(5*5)+(4*8)+(3*8)+(2*4)+(1*0)=243
243 % 10 = 3
So 949588-40-3 is a valid CAS Registry Number.
