94988-89-3

Upstream product

• 67-52-7 BARBITURIC ACID 
• 2698-41-1 o-chlorobenzylidene malononitrile 
• 89-98-5 2-chloro-benzaldehyde 
• 109-77-3 malononitrile 
• 67-52-7 pyrimidine-2,4,6-triol 

Relevant academic research and scientific papers

Green synthesis of pyrano[2,3-d]-pyrimidine derivatives in ionic liquids

Pyrano[2,3-d]pyrimidine derivatives were synthesized in high yields by a condensation reaction between arylmethylidenemalononitrile and barbituric acid using room-temperature ionic liquids such as 1-n-butyl-3-methylimidazolium tetrafluoroborate ([BMIm]BF

Efficient biogenesis of Cu2O nanoparticles using extract of Camellia sinensis leaf: Evaluation of catalytic, cytotoxicity, antioxidant, and anti-human ovarian cancer properties

At the moment, metallic nanoparticles especially copper nanoparticles are administrated for the cure of different disorders, such as tumor and cancer. In recent years, many chemotherapeutic supplements have been formulated by copper nanoparticles. In the

SCMNPs@Urea/Py-CuCl2: a recyclable catalyst for the synthesis of pyrano[2,3-d]pyrimidinone and pyrano[2,3-d] pyrimidine-2,4,7-trione derivatives

An efficient, simple, and mild strategy for the one-pot multicomponent synthesis of pyrano[2,3-d]pyrimidinone and pyrano[2,3-d]pyrimidine-2,4,7-trione derivatives is described using SCMNPs@Urea/Py-CuCl2 nanoparticles as a reusable heterogeneous magnetic nanocatalyst. The catalyst was characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The SCMNPs@Urea/Py-CuCl2 can be easily collected from the reaction solution by magnetic decantation using a permanent magnetic field and reused in six runs without significant decrease in catalytic activity.

An efficient one-pot three-component synthesis of 7-amino-2, 4-dioxo-5-aryl-1,3,4,5-tetrahydro-2 H-pyrano[2,3-d]pyrimidine-6-carbonitriles catalyzed by SnO2/SiO2 nanocomposite

Abstract: We have developed a SnO2/SiO2 catalyzed efficient and rapid protocol for the synthesis of pyrano[2,3-d]pyrimidinone derivatives by the three-component cyclocondensation of aromatic benzaldehydes, malononitrile, and barbitur

A choline chloride-based deep eutectic solvent promoted three-component synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d] pyrimidinone (thione) derivatives

An efficient one-pot method for the synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone (thione) derivatives through a three-component reaction between aldehydes, malononitrile and enolizable C–H activated acidic compounds using a new deep eutectic solvent made of choline chloride, urea and thiourea as an environmentally benign catalyst has been reported. The structure of the catalyst was characterized using FT-IR, 1H NMR, and 13C NMR. The present method exhibits some notable advantages such as ease of the preparation and handling of the catalyst, low cost, green reaction conditions, short reaction times, high yields, and simple work-up. Also, the catalyst could be recovered easily and recycled up to four times without significant loss of catalytic activity.

Nano-ZnO Impregnated on Starch—A Highly Efficient Heterogeneous Bio-Based Catalyst for One-Pot Synthesis of Pyranopyrimidinone and Xanthene Derivatives as Potential Antibacterial Agents

Abstract: A new method has been proposed for the synthesis of pyranopyrimidinone andxanthene derivatives using zinc oxide–starch nanocomposite as catalyst undermicrowave irradiation. The ZnO–starch nanocomposite was characterized by X-raydiffraction and s

Fe3O4@SiO2-BenzIm-Fc[Cl]/ZnCl2: a novel and efficient nano-catalyst for the one-pot three-component synthesis of pyran annulated bis-heterocyclic scaffolds under ultrasound irradiation

In this study, a novel magnetically recoverable Fe3O4@SiO2-BenzIm-Fc[Cl]/ZnCl2 nano-particle was synthesized using a simple chemical coprecipitation approach. In the FT-IR spectroscopy of nano-particles, related

Synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone derivatives using Fe3O4@Ph-PMO-NaHSO4 as a new magnetically separable nanocatalyst

Immobilized NaHSO4 on core/shell phenylene bridged periodic mesoporous organosilica magnetic nanoparticles (Fe3O4@Ph-PMO-NaHSO4) as a new acidic magnetically separable nanocatalyst was successfully prepared in three steps: (i) preparation of Fe3O4 nanoparticles by a precipitation method, (ii) synthesis of an organic-inorganic periodic mesoporous organosilica structure with phenyl groups on the surface of Fe3O4 magnetic nanoparticles (MNPs) and (iii) finally adsorption of NaHSO4 on periodic mesoporous organosilica (PMO) network. The prepared organic-inorganic magnetic reagent was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), N2 adsorption-desorption and energy-dispersive X-ray (EDX) techniques. Finally, it was used as a reusable and new catalyst to promote the synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone derivatives as important biologically active compounds. Eco-friendly protocol, high yields, short reaction times and easy and quick isolation of the products are the main advantages of this procedure.

SO3H-functionalized nano-MGO-D-NH2: Synthesis, characterization and application for one-pot synthesis of pyrano[2,3-d]pyrimidinone and tetrahydrobenzo[b]pyran derivatives in aqueous media

An SO3H-functionalized nano-MGO-D-NH2 catalyst has been prepared by multi-functionalization of a magnetic graphene oxide (GO) nanohybrid and evaluated in the synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone derivati

Synthesis of chloro, fluoro, and nitro derivatives of 7-amino-5-aryl-6-cyano-5H-pyrano pyrimidin-2,4-diones using organic catalysts and their antimicrobial and anticancer activities

Chloro, fluoro, and nitro derivatives of 7-amino-5-aryl-6-cyano-5H-pyrano pyrimidin-2,4-diones were produced by reacting malononitrile, barbituric acid, and aromatic aldehydes together with a DABCO catalyst in an aqueous one-pot reaction. This is the firs