94989-13-6Relevant academic research and scientific papers
SELECTIVE N-METHYLATION OF PEPTIDE BOND. PREPARATION AND PROPERTIES OF 2,2', D-MePhe4,4'> GRAMICIDIN S
Kawai, Masao,Ohya, Masashi,Butsugan, Yasuo,Saito, Kazuki,Higashijima, Tsutomu
, p. 1835 - 1836 (2007/10/02)
Diphthaloyl derivative of gramicidin S was subjected to selective N-methylation using CH3I-Ag2O in DMF.Methylation occurred exclusively at ornithine and D-phenylalanine residues affording tetra-N-methylated product in high yield.Removal of the phthaloyl g
