949902-57-2Relevant academic research and scientific papers
Disubstituted alkyl-8-azabicyclo[3.2.1] octane compounds as mu opioid receptor antagonists
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Page/Page column 12, (2009/04/24)
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provid
Crystalline forms of an 8-Azabicyclo(3.2.1)octane compound
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Page/Page column 10, (2008/12/08)
The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising s
8-Azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
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Page/Page column 26-27, (2008/06/13)
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
