949913-76-2Relevant academic research and scientific papers
Heterocyclic α-helix mimetics for targeting protein-protein interactions
Biros, Shannon M.,Moisan, Lionel,Mann, Enrique,Carella, Alexandre,Zhai, Dayong,Reed, John C.,Rebek Jr., Julius
, p. 4641 - 4645 (2007)
The design and synthesis of α-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-XL interaction was tested using an in vitro fluorescence polarization assay.
