949926-09-4

Basic information

• Product Name: 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-1-(ethylcarbamoyl-hydroxy-methyl)-2,2-diphenyl-ethylcarbamoyl]-2-methyl-propyl}-amide
• CAS NO: 949926-09-4
• Molecular Weight: 585.832
• Mol File: 949926-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-1-(ethylcarbamoyl-hydroxy-methyl)-2,2-diphenyl-ethylcarbamoyl]-2-methyl-propyl}-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-1-(ethylcarbamoyl-hydroxy-methyl)-2,2-diphenyl-ethylcarbamoyl]-2-methyl-propyl}-amide(949926-09-4)
• EPA Substance Registry System: 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-1-(ethylcarbamoyl-hydroxy-methyl)-2,2-diphenyl-ethylcarbamoyl]-2-methyl-propyl}-amide(949926-09-4)

Safety Data

• Hazardous Substances Data: 949926-09-4(Hazardous Substances Data)

Upstream product

• 949925-90-0 (S)-2-Amino-N-[(S)-1-(ethylcarbamoyl-hydroxy-methyl)-2,2-diphenyl-ethyl]-3-methyl-butyramide 
• 1077-28-7 Thioctic acid 
• 138662-63-2 (2S)-2-tert-butoxycarbonylamino-3,3-diphenyl-propionic acid 
• 949923-60-8 [1-(methoxy-methyl-carbamoyl)-2,2-diphenyl-ethyl]-carbamic acid tert-butyl ester 
• 155806-49-8 (1-formyl-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy

Dipeptide-derived α-keto-amide compounds with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC50 values down to 25 nM and exhibit greatly improved activity in muscle cells compared to the reference compound MDL28170. Several novel calpain inhibitors have shown positive effects on histological parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease.