949928-48-7

Upstream product

• 593267-69-7 methyl 4-((1H-indol-3-yl)methyl)benzoate 
• 120-72-9 indole 
• 1571-08-0 methyl 4-formylbenzoate 

Relevant academic research and scientific papers

Synthesis of C3-Alkylated Indoles on DNA via Indolyl Alcohol Formation Followed by Metal-Free Transfer Hydrogenation

3-Alkylated indole cores have been found in countless natural products and many biologically active compounds, including pharmaceuticals. In this report, a highly efficient approach to C3-alkylated indole derivatives on DNA via indolyl alcohol formation f

ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND METHODS

The presently-disclosed subject matter generally relates to antimicrobial compounds, compositions, methods of making and methods of use thereof. The presently-disclosed subject matter further relates to compounds, compositions and methods for the control of Porphyromonas gingivalis.

Novel zafirlukast derivatives exhibit selective antibacterial activity against: Porphyromonas gingivalis

Periodontal disease is an oral chronic immune-inflammatory disease highly prevalent worldwide that is initiated by specific oral bacterial species leading to local and systemic effects. The development of new preventive/therapeutic strategies to specifically target oral periodontopathogens without perturbing oral microbiome species normally colonizing the oral cavity is needed. The fast and affordable strategy of repositioning of already FDA-approved drugs can be an answer to the development of novel treatments against periodontal pathogens such as Porphyromonas gingivalis. Herein, we report the synthesis and antibacterial activity of novel zafirlukast derivatives, their bactericidal effect, and their cytotoxicity against oral epithelial cell lines. Many of these derivatives exhibited superior antibacterial activity against P. gingivalis compared to the parent drug zafirlukast. The most promising compounds were found to be selective against P. gingivalis and they were bactericidal in their activity. Finally, we demonstrated that these potent derivatives of zafirlukast provided a better safety profile against oral epithelial cells compared to zafirlukast.

N-substituted-azacyclylamines as histamine-3 antagonists

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.