949932-68-7

Upstream product

• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 32780-08-8 (5S)-5-[(benzyloxy)methyl]dihydrofuran-2(3H)-one 
• 949932-67-6 (S)-5-(benzyloxy)pentane-1,4-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 949932-69-8 C₂₇H₄₀O₄SiS 
• 949932-71-2 C₂₇H₄₀O₄SiS 
• 1220511-39-6 (4S)-5-benzyloxy-4-methoxypentan-1-al 
• 1220511-37-4 (4S)-5-benzyloxy-4-methoxypentan-1-ol 
• 949932-49-4 C₂₁H₂₆O₅S 
• 949932-42-7 C₂₁H₂₆O₄S 
• 949932-37-0 C₂₁H₂₄O₄S 
• 949932-72-3 C₂₁H₂₆O₄S 
• 949932-47-2 C₂₁H₂₆O₅S 
• 949932-40-5 C₂₁H₂₆O₄S 
• 949932-36-9 C₂₁H₂₄O₄S 
• 949932-70-1 C₂₁H₂₆O₄S 

Relevant academic research and scientific papers

Practical synthesis of C1-8 fragment of autolytimycin via a chelation-controlled diastereoselective addition of diisopropenylzinc to α-methoxy aldehyde

The C1-8 fragment of autolytimycin was synthesized via a reliable 10-step route capable of delivering 41% overall yield at multi-gram scale. As a key step, a chelation-controlled isopropenylation of α-oxygenated aldehydes was established with a reagent combination of diisopropenylzinc, magnesium halide, and a dichloromethane/toluene mixed solvent. Cram-chelate isopropenylation products dominated for aldehydes with a small α-substituents, such as -OMe and -OBn groups, while the Felkin product could be obtained with a bulky -OTBS group.

Efficient chirality transfer in the Sml2-mediated cyclization of aldehydo β-alkoxyvinyl sulfoxides: Asymmetric synthesis of 3-hydroxyoxanes

Stereoselective syntheses of 3-hydroxyoxanes were achieved via efficient chirality transfer in the Sml2-mediated cyclization reactions of aldehydo β-alkoxyvinyl sulfoxides.