949934-22-9Relevant academic research and scientific papers
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents
Brogi, Simone,Brindisi, Margherita,Joshi, Bhupendra P.,Sanna Coccone, Salvatore,Parapini, Silvia,Basilico, Nicoletta,Novellino, Ettore,Campiani, Giuseppe,Gemma, Sandra,Butini, Stefania
supporting information, p. 5412 - 5418 (2015/11/09)
We report herein the generation and validation of a 3D-QSAR model based on a set of antimalarials previously described by us and characterized by a clotrimazole-based pharmacophore. A novel series of derivatives was synthesized and showed activity against
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE
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Page/Page column 31, (2010/11/28)
Antimalarial agents having a novel pharmacophore of formula (I) are herein described. These polycyclic compounds are able to inhibit chloroquine-sensitive and chloroquine-resistant strains ofPlasmodium falciparum (Pf). Furthermore, the synthesis of these compounds involves few steps from commercial products with low cost of production.Λa présente invention concerne des agents antimalariaux comportant un nouveau pharmacophore de formule (I). Ces composés polycycliques sont susceptibles d''inhiber les souches sensibles à la chloroquine et résistantes à la chloroquine de Plasmodium falciparum (Pf). En outre, la synthèse de ces composés est peu onéreuse et implique peu d''étapes à partir des produits commerciaux.
