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950-37-8

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950-37-8 Usage

Description

Different sources of media describe the Description of 950-37-8 differently. You can refer to the following data:
1. Methidation is used as an insecticide. Cross-sensitivity was described to dichlorvos.
2. Methidathion is an organophosphate insecticide that inhibits insect cholinesterase. It reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% when administered topically at a dose of 3.5 mg/kg. Methidathion is selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival when administered topically at a dose of 24 mg/kg. It increases sister chromatid exchange (SCE) in a concentration-dependent manner and induces cell cycle arrest at the M1 phase in V79 cells when used at a concentration of 40 μg/ml. Dietary administration of methidathion (1.4-4.7 mg/kg) increases alanine aminotransferase, aspartate aminotransferase, sorbitol dehydrogenase, and alkaline phosphatase activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs. It also induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats when administered orally at a dose of 5 mg/kg.

Chemical Properties

Different sources of media describe the Chemical Properties of 950-37-8 differently. You can refer to the following data:
1. Crystalline solid. Almost insoluble in water; soluble in common organic solvents.
2. Methidathion is a colorless crystalline pesticide at room temperature. It is sparingly soluble in water, but very soluble in octanol, ethanol, xylene, acetone, and cyclohexane. Methidathion is a non-systemic organophosphorous insecticide and acaricide with stomach and contact action. It is used to control a variety of insects and mites on crops and fruit plants. Methidathion is highly toxic to animals and humans. The US EPA grouped methidathion as a class I toxic substance and as an RUP.
3. Methidathion is a colorless crystalline solid.

Uses

Different sources of media describe the Uses of 950-37-8 differently. You can refer to the following data:
1. Methidathion is an organophosphate insecticide and was examined for human health and toxicological concerns.
2. Methidathion is used to control a wide range of insects in many different crops.

General Description

Methidathion is a colourless crystalline pesticide at room temperature. It is sparingly soluble in water but very soluble in octanol, ethanol, xylene, acetone, and cyclohexane.

Air & Water Reactions

Stable in neutral or weak acid solution. Hydrolyzed by alkali. [EPA, 1998].

Reactivity Profile

Organophosphates, such as Methidathion, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

Toxic by ingestion, a cholinesterase inhibitor.

Health Hazard

Different sources of media describe the Health Hazard of 950-37-8 differently. You can refer to the following data:
1. Methidathion is poisonous to humans. Its toxic effects are by action on the nervous system. Human volunteers ingesting 0.11 mg/kg/day for 6 weeks had no clinical effects.
2. Acute and prolonged exposures to methidathion cause poisoning in animals and humans. The symptoms include, but are not limited to, nausea, vomiting, cramps, diarrhea, salivation, headache, dizziness, muscle twitching, diffi culty breathing, blurred vision, and tightness in the chest, pulmonary edema, respiratory depression, and respiratory paralysis. Acute exposures to high concentrations of methidathion cause intense breathing problems, including paralysis of the respiratory muscles.

Fire Hazard

(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Stable in neutral or weak acid solution. Hydrolyzed by alkali.

Agricultural Uses

Insecticide: A U.S. EPA restricted Use Pesticide (RUP). Not approved for use in EU countries . There are no residential uses for methidathion. Methidathion is a non-systemic organophosphate insecticide and acaricide with stomach and contact action. The compound is used to control a variety of insects and mites in many crops such as nuts, artichokes, olives, cotton, fruits, vegetables, tobacco, alfalfa, and sunflowers, and also in greenhouses and on rose cultures. It is especially useful against scale insects.

Trade name

CIBA-GEIGY? GS 13005?; COBRACIDE?; FISONS NC? 2964; GEIGY? 13005; GS-13005?; SOMONIC?; SOMONIL?; SURPRACIDE?; SUPRATHION?; ULTRACID?; ULTRACIDE?

Contact allergens

Methidation is an organophosphorus compound used as an insecticide. Cross-sensitivity was described to Dichlorvos.

Safety Profile

Poison by ingestion and skin contact. Moderately toxic by inhalation. Human mutation data reported. Human systemic effects: coma, lachrymation, miosis. A severe eye irritant. An insecticide. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx

Carcinogenicity

In a chronic toxicity/carcinogenicity study, rats were fed diets with 0, 4, 40, or 100 ppm methidathion (equivalent to 0, 0.16, 1.72, or 4.91 mg/kg/day (males) and 0, 0.22, 2.20, or 6.93 mg/kg/day (females)) for 2 years, and there was no evidence of carcinogenicity in either males or females . Body weight decreases occurred in both sexes at the highest dose throughout the study.

Environmental Fate

Photolytic. When methidathion in an aqueous buffer solution (25°C and pH 7.0) was exposed to filtered UV light (l >290 nm) for 24 hours, 17% decomposed to 5-methoxy- 3H-1,3,4-thiadiazol-2-one. At 50°C, 56% was degraded after 24 hours. Degradation occurred via hydrolysis of the thiol bond of the phosphorodithioic ester. Under acidic and alkaline conditions, hydrolytic cleavage occurred at the C-S and P-S bonds, respectively (Burkhard and Guth, 1979). Smith et al. (1978) demonstrated that methidathion degraded to methidathion oxon at a faster rate in six air-dried soils than in moist soils. Half-lives for methidathion in the air-dried soils ranged from 19 to 110 days. In addition, methidathion degraded faster in an air-dried soil exposed to ozone (half-lives 2.5 to 7.0 days).Chemical/Physical. Emits toxic fumes of phosphorus, nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987). Methidathion oxon was also found in fogwater collected near Parlier, CA (Glotfelty et al., 1990). It was suggested

Metabolic pathway

The main route of methidathion metabolism in animals and plants is via hydrolysis or oxidation (or hydrolysis of the oxon) to yield the 3- thiomethyl-5-methoxy-1,3,4-thiadiazoldee rivative. This may either lose methanethiol to yield the methoxy-1,3,4thiadiazolinone or be conjugated as the cysteine derivative via a route involving desmethylmethidathion (in plants). In plants and mammals an additional route involves the methylation of the thiomethyl methoxy-1,3,4-thiadiazolinone derivative by S-adenosylmethionine followed by oxidation to the corresponding sulfoxide and sulfone which are excreted in the urine in mammals. Another route of detoxification in insects, plants and mammals is via demethylation of the 5-methoxy group of the 1,3,4-thiadiazolinone ring to form a metabolite which may be conjugated in plants. As is common with many phosphorothioates, the active acetylcholinesterase inhibitor, methidaoxon, is usually detected in metabolism studies but at very low concentration due to its rapid rate of hydrolysis.

Metabolism

The principal degradation route is similar both in animals and plants, that is, cleavage of the P?S bond via oxidative desulfuration (activation) to the oxon followed by hydrolysis to O,O-dimethyl hydrogen phosphorothioate and the 3-thiomethyl-5-methoxythiadiazole derivative, which is further degraded or conjugated. Methidathion is rapidly degraded in soil; DT50 in soil is 3–18 d.

Shipping

Color code—Blue: Health Hazard/Poison: Store in a secure poison location. Prior to working with this chemical, personnel should be trained on its proper handling and storage. Store in tightly closed containers in a cool, wellventilated area

Toxicity evaluation

The acute oral LD50 for rats is 25–54 mg/kg. Inhalation LC50 (4 h) for rats is 3.6 mg/L air. NOEL (2 yr) for rats is 4 mg/kg diet (0.2 mg/kg/d). ADI is 1 μg/kg b.w. Methidathion administered to animals is rapidly metabolized and excreted.

Degradation

Methidathion is rapidly hydrolysed in alkaline solution but it is relatively stable in neutral and slightly acidic media. The DT50 for hydrolysis at pH 13 (25 °C) was 30 min (PM).

Waste Disposal

Treat with strong alkali, mix with soil and bury in the case of small quantities. For large quantities, use incineration with effluent gas scrubbing

Precautions

Occupational workers should be very careful during use and chemical management of methidathion. As this chemical substance is a highly toxic pesticide, it has been grouped by the US EPA as toxicity class I. The containers and labels of the products should bear the signal word DANGER. Methidathion is an RUP, except for use in nurseries, and on saffl ower and sunfl owers.

Check Digit Verification of cas no

The CAS Registry Mumber 950-37-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,5 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 950-37:
(5*9)+(4*5)+(3*0)+(2*3)+(1*7)=78
78 % 10 = 8
So 950-37-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H11N2O4PS3/c1-10-5-7-8(6(9)16-5)4-15-13(14,11-2)12-3/h4H2,1-3H3

950-37-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methidathion

1.2 Other means of identification

Product number -
Other names faat

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Insecticide
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:950-37-8 SDS

950-37-8Relevant articles and documents

Macrocyclic plant acaricides

-

, (2008/06/13)

Compounds of the formula I STR1 in which either R is methyl and there is a double bond in the 9,10-position, or in which R is hydrogen and there is a single bond in the 9,10-position, are highly active against Acarina which damage plants.

On the chemistry of GS 13005, a new insecticidal phosphoric acid ester

Ruefenacht

, p. 518 - 526 (2007/10/04)

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