Z-Tyr-Ava-PHA, also known as Z-Tyr-Ala-Ala-Pro-His-Ala-OH, is a synthetic peptide that serves as a potent and selective inhibitor of the enzyme neutrophil elastase. This enzyme plays a crucial role in the degradation of proteins in the extracellular matrix, and its dysregulation is associated with various inflammatory and lung diseases, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The peptide is designed to mimic the natural substrate of neutrophil elastase, with the addition of a Z group (benzyloxycarbonyl) and an Ava (3-amidinophenylpropionic acid) to enhance its binding affinity and specificity. By inhibiting neutrophil elastase, Z-Tyr-Ava-PHA can help reduce inflammation and protect lung tissue from damage, making it a potential therapeutic agent for respiratory conditions characterized by excessive elastase activity.

95015-83-1

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Basic information
1. Product Name: Z-Tyr-Ava-PHA
2. Synonyms: Z-Tyr-Ava-PHA
3. CAS NO:95015-83-1
4. Molecular Formula:
5. Molecular Weight: 517.625
6. EINECS: N/A
7. Product Categories: N/A
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: N/A
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: Z-Tyr-Ava-PHA(CAS DataBase Reference)
10. NIST Chemistry Reference: Z-Tyr-Ava-PHA(95015-83-1)
11. EPA Substance Registry System: Z-Tyr-Ava-PHA(95015-83-1)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 95015-83-1(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 95015-83-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,0,1 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 95015-83:
(7*9)+(6*5)+(5*0)+(4*1)+(3*5)+(2*8)+(1*3)=131
131 % 10 = 1
So 95015-83-1 is a valid CAS Registry Number.

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