95016-53-8

Basic information

• Product Name: 6-methyl-2-[(3-pyridinylmethyl)sulfanyl]-4(3H)-pyrimidinone
• Synonyms: 6-methyl-2-[(3-pyridinylmethyl)sulfanyl]-4(3H)-pyrimidinone
• CAS NO: 95016-53-8
• Molecular Formula: C11H11N3OS
• Molecular Weight: 233.28954
• Mol File: 95016-53-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-methyl-2-[(3-pyridinylmethyl)sulfanyl]-4(3H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2-[(3-pyridinylmethyl)sulfanyl]-4(3H)-pyrimidinone(95016-53-8)
• EPA Substance Registry System: 6-methyl-2-[(3-pyridinylmethyl)sulfanyl]-4(3H)-pyrimidinone(95016-53-8)

Safety Data

• Hazardous Substances Data: 95016-53-8(Hazardous Substances Data)

Upstream product

• 56-04-2 6-methyl-2-thiouracil 
• 4916-55-6 3-(bromomethyl)pyridine hydrobromide 
• 6959-48-4 3-chloromethylpyridinium chloride 

Relevant articles and documents

Synthesis of novel pyrimidine derivatives with (pyridin-3-ylmethyl)thio and phenylamino moieties and evaluation of their antifungal activity

A series of novel pyrimidine derivatives with (pyridin-3-ylmethyl)thio and phenylamino moieties were synthesized from ethyl acetoacetate, thiourea, 3-pyridinylmethyl chloride hydrochloride, and substituted anilines by multi-step reactions. The structures of the target compounds were characterized by IR, 1H NMR, 13C NMR and elemental analysis. The in vitro antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were evaluated. The result showed that N-phenyl-6-methyl-2- ((pyridin-3-ylmethyl)thio) pyrimidin-4-amine (4a) displayed high inhibition activity against Botrytis cinerea with 87.5%inhibition at 100?μg/mL; 4a, and N-(4-isopropylphenyl)-6-methyl-2-((pyridin-3-ylmethyl)thio)pyrimidin-4-amine (4c), N-(4-methoxyphenyl)-6-methyl-2-((pyridin-3-ylmethyl)thio)pyrimidin-4-amine (4d) and N-(2-hydroxy-5-chloro)-6-methyl-2-((pyridin-3-ylmethyl)thio)pyrimidin- 4-amine (4h) exhibited sufficient activities against Sclerotinia sclerotiorum with 86.6% –93.7% inhibitions at the same concentration.

2-pyrimidine Derivatives: New Bronchosecretolytic Agents

2-pyrimidine derivatives (1a-n) promote the excretion of phenol red into the mouse trachea, indicating an increased tracheobronchial secretion.Furthermore, 2-pyrimidine (1a) (tasuldine) produces greater ex