95017-91-7

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 58656-98-7 tert-butyl 4-fluorobenzoate 

Downstream Products

• 95017-68-8 1-<4-(tert-butyloxycarbonyl)phenyl>-4-piperidinone 
• 95017-84-8 1-<4-(tert-butoxycarbonyl)phenyl>-3-(aminomethylene)-4-piperidone 
• 95017-70-2 1-<4-(tert-butoxycarbonyl)phenyl>-4-(N-pyrrolidino)-1,2,5,6-tetrahydropyridine 
• 95017-77-9 2-amino-3-cyano-6-(4-carboxyphenyl)-5,6,7,8-tetrahydropyrido<4,3-b>pyridine 
• 95017-74-6 2-amino-3-cyano-6-<4-(tert-butoxycarbonyl)phenyl>-5,6,7,8-tetrahydropyrido<4,3-b>pyridine 
• 95017-78-0 2,4-diamino-7-(4-carboxyphenyl)-5-deaza-6,7,8,9-tetrahydropyrido<3,4-g>pteridine 
• 95044-85-2 4-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-1,3,6,9-tetraaza-anthracen-6-yl)-benzoic acid 
• 95017-85-9 2-amino-7-<4-(tert-butoxycarbonyl)phenyl>-5-deaza-6,7,8,9-tetrahydro-4(3H)-pyrido<3,4-g>pteridinone 
• 95017-76-8 2,4-diamino-7-<4-(tert-butoxycarbonyl)phenyl>-5-deaza-6,7,8,9-tetrahydropyrido<3,4-g>pteridine 
• 95017-87-1 2-acetamido-7-(4-carboxyphenyl)-5-deaza-6,7,8,9-tetrahydro-4(3H)-pyrido<3,4-g>pteridinone 
• 95017-72-4 4-[5-(2,2-Dicyano-vinyl)-4-pyrrolidin-1-yl-3,6-dihydro-2H-pyridin-1-yl]-benzoic acid tert-butyl ester 
• 95017-86-0 2-acetamido-7-<4-(tert-butoxycarbonyl)phenyl>-5-deaza-6,7,8,9-tetrahydro-4(3H)-pyrido<3,4-g>pteridinone 
• 95017-92-8 C₂₁H₁₉N₅O₅ 
• 95017-89-3 L-7,10-ethano-5-deazafolic acid 

Relevant academic research and scientific papers

CEREBLON E3 LIGASE INHIBITORS

The present disclosure provides compounds represented by Formula I: wherein R2a, R2b, R2c, R2d, R3, R13, and Z are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are cereblon (CRBN) ubiquitination inhibitors or monofunctional synthetic intermediates that can be used to prepare PROTAC molecules. CRBN ubiquitination inhibitors and PROTAC molecules are useful for the treatment of cancer and other diseases.

ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND

The present disclosure provides compounds represented by Formula I : A-L-B 1 I, and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. ompounds having Formula I are androgen receptor degraders useful for the treatment of ancer and other diseases.

Synthesis of D,L-7,10-Ethano-5-deazaaminopterin and L-7,10-Ethano-5-deazafolic Acid

The title compounds have been prepared by several different ring annulation procedures starting from 1--4-piperidone (6b).