950172-26-6

Basic information

• Product Name: (S)-(+)-(N-benzyloxycarbonyl)-(4,4-di(p-chlorobenzyl)pyrrolidin-2-yl)methan-1-ol
• Synonyms: (S)-(+)-(N-benzyloxycarbonyl)-(4,4-di(p-chlorobenzyl)pyrrolidin-2-yl)methan-1-ol
• CAS NO: 950172-26-6
• Molecular Weight: 484.422
• Mol File: 950172-26-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(+)-(N-benzyloxycarbonyl)-(4,4-di(p-chlorobenzyl)pyrrolidin-2-yl)methan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-(N-benzyloxycarbonyl)-(4,4-di(p-chlorobenzyl)pyrrolidin-2-yl)methan-1-ol(950172-26-6)
• EPA Substance Registry System: (S)-(+)-(N-benzyloxycarbonyl)-(4,4-di(p-chlorobenzyl)pyrrolidin-2-yl)methan-1-ol(950172-26-6)

Safety Data

• Hazardous Substances Data: 950172-26-6(Hazardous Substances Data)

Upstream product

• 99208-71-6 (5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane 
• 950172-17-5 (5S)-1-aza-2,2-dimethyl-7,7-di(p-chlorobenzyl)-3-oxa-8-oxo-bicyclo[3.3.0]octane 
• 950172-21-1 (5S)-3,3-di(p-chlorobenzyl)-5-hydroxymethylpyrrolidin-2-one 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

4,4′-Disubstituted L-prolines as highly enantioselective catalysts for direct aldol reactions

A new series of 4,4′-disubstituted prolines (1a-h) has been developed and tested as organocatalysts in the direct catalytic asymmetric aldol reaction of several aliphatic ketones with aldehydes. Catalyst 1g affords the best enantioselectivities for this transformation. The reaction was carried out in DMF using a catalyst loading of 10 mol% at -10°C to give the aldol products in up to 97% ee for acetone. In the cases of cyclohexanone and cyclopentanone, the corresponding anti-products were obtained in 94% ee.