950202-94-5Relevant academic research and scientific papers
Triple-helical transition state analogues: A new class of selective matrix metalloproteinase inhibitors
Lauer-Fields, Janelle,Brew, Keith,Whitehead, John K.,Li, Shunzi,Hammer, Robert P.,Fields, Gregg B.
, p. 10408 - 10417 (2007)
Alterations in activities of one family of proteases, the matrix metalloproteinases (MMPs), have been implicated in primary and metastatic tumor growth, angiogenesis, and pathological degradation of extracellular matrix (ECM) components, such as collagen
SELECTIVE INHIBITION OF MATRIX METALLOPROTEINASES
-
Page/Page column 25; 29, (2010/11/27)
Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple- helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.
