950236-92-7

Upstream product

• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 

Downstream Products

• 1383375-34-5 (E)-6-bromo-3-(4-(3-(4-chlorophenyl)acryloyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-35-6 (E)-6-bromo-3-(4-(3-(4-nitrophenyl)acryloyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-37-8 (E)-6-bromo-3-(4-(3-(4-fluorophenyl)acryloyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-39-0 (E)-6-bromo-3-(4-(3-(4-(dimethylamino)phenyl)acryloyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-40-3 (E)-6-bromo-3-(4-(3-(4-methoxyphenyl)acryloyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-42-5 (E)-6-bromo-2-(pyridin-4-yl)-3-(4-(3-(thiophen-2-yl)acryloyl)phenyl)quinazolin-4(3H)-one 
• 1383375-44-7 (E)-6-bromo-3-(4-(3-(furan-2-yl)acryloyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-46-9 6-bromo-3-(4-(2-bromoacetyl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-48-1 3-(4-(2-aminothiazol-4-yl)phenyl)-6-bromo-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-49-2 6-bromo-2-(pyridin-4-yl)-3-(4-(2-thiocyanatoacetyl)phenyl)quinazolin-4(3H)-one 
• 1383375-51-6 6-bromo-3-(4-(2-hydroxythiazol-4-yl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-53-8 6-bromo-3-(4-(6-(4-chlorophenyl)-2-oxo-1,2,5,6-tetrahydropyrimidin-4-yl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-55-0 6-bromo-3-(4-(1-methyl-5-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 
• 1383375-57-2 6-bromo-3-(4-(5-(4-(dimethylamino)phenyl)-4,5-dihydroisoxazol-3-yl)phenyl)-2-(pyridin-4-yl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Design, synthesis, anti-inflammatory, analgesic screening, and molecular docking of some novel 2-pyridyl (3H)-quinazolin-4-one derivatives

A novel series of 6-bromo-2-(4-pyridyl)-quinazolin-4(3H)-ones were synthesized by reacting 5-bromo anthranilic acid with isonictinoly chloride in the presence of acetic anhydride, which were further reacted with p-amino acetophenone to obtain 3-(4-acetylphenyl)-6-bromo-2-(pyridin-4-yl)quinazolin- 4(3H)-one (3). Compound 3 underwent further reactions with different aldehydes to afford chalcone derivatives 4-10, which in turn underwent various cyclization reactions to afford cyclized products 15-18. 2-aminothiazole derivatives 12 obtained by reaction of 3 with bromine then with thiourea. Compound 14 obtained by treatment of 11 with KSCN followed by cyclization. Some of the synthesized compounds 4, 5, 12, 14, 15 and 18 were screened for both analgesic and anti-inflammatory activities. All tested compounds showed good analgesic and anti-inflammatory activity in comparison to the reference standard indomethacin. Compounds 4 and 5 showed the highest anti-inflammatory activity, while compounds 14 and 15 showed the highest analgesic activity among all the tested compounds.

Synthesis and biological evaluation studies of some novel quinazoline and quinazolinone derivatives as anti-liver cancer agents

HIS ARTICLE describes the synthesis of some novel quinazoline ...T.. (4-24) and quinazolinone (3, 25-29) derivatives, starting with 5-bromo-2-isonicotinamido-benzoic acid (1). The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectral data. The compounds (4, 6, 7, 8, 10, 12, 18, 19, 23, 25) were evaluated for their in-vitro anticancer activity against human liver cancer cell line (HEPG2). Most of the screened compounds showed interesting cytotoxic activity compared to 5-Flurouracil as a reference drug.