950415-76-6Relevant academic research and scientific papers
Isomeric 3-isoxadiazolylcoumarins and their derivatives
Detistov, Oleksandr S.,Orlov, Valeriy D.,Zhuravel', Irina O.
, p. 883 - 892 (2012/10/29)
Here, we represent preparative methods of synthesis of isomeric 3-isoxadiazolylcoumarins and their derivatives. Two new synthetic methods have been developed for 3-[1,2,4-oxadiazol-5-yl]coumarins I. The first method is based on a three-component condensation of coumarin-;3-carboxylic acids, 1,1'-carbonyldiimidazole, and amidoximes. The second method essentially uses the interaction of 5-cyanomethyl-1,2,4-oxadiazoles with salicylic aldehydes. General approach for preparation of 3-[1,2,4-oxadiazol-3-yl]coumarins II has been worked out. Moreover, aforementioned synthetic ways open the way for the synthesis of 2-iminoderivatives III and IV not described before, those were diversified by reaction of nucleophilic substitution of 2-imino group with a numerous amino compounds.
