95043-81-5

Upstream product

• 481-29-8 Epiandrosterone 
• 53-43-0 dehydroepiandrosterone 
• 10481-80-8 3β-hydroxy-17-hydrozone-5α-androstane 
• 10481-80-8 3β-hydroxy-5α-androstan-17-one hydrazone 
• 1239-31-2 3β-acetoxy-5α-androstan-17-one 

Downstream Products

• 1153-51-1 3β-Hydroxy-androst-16-en 
• 219843-75-1 (3β,5α)-17-(3'-pyridinyl)androst-16-en-3-ol 
• 694438-95-4 (3β,5α)-17-phenylandrost-16-en-3-ol 
• 7148-51-8 5α-androst-16-en-3β-ol 
• 18339-16-7 5α-androst-16-en-3-one 

Relevant academic research and scientific papers

Synthetic method of androst-16-en-3beta-ol

The invention discloses a synthetic method of androst-16-en-3beta-ol. According to the method, 17-iodoandrosta-16-en-3beta-ol is subjected to deiodination in an organic solvent under the protection ofargon under the action of alkali metal alkoxide to prepare androst-16-en-3beta-ol. The synthetic method is simple and convenient to operate, avoids the use of metallic sodium and lithium alkyl reagents, and has relatively mild conditions.

Synthesis, Characterization, and Biological Properties of Steroidal Ruthenium(II) and Iridium(III) Complexes Based on the Androst-16-en-3-ol Framework

A range of novel cyclometalated ruthenium(II) and iridium(III) complexes with a steroidal backbone based on androsterone were synthesized and characterized by NMR spectroscopy and X-ray crystallography. Their cytotoxic properties in RT112 and RT112 cP (cisplatin-resistant) cell lines as well as in MCF7 and somatic fibroblasts were compared with those of the corresponding nonsteroidal complexes and the noncyclometalated pyridyl complexes as well as with cisplatin as reference. All steroidal complexes were more active in RT112 cP cells than cisplatin, whereby the cyclometalated pyridinylphenyl complexes based on 5c showed high cytotoxicity while maintaining low resistant factors of 0.33 and 0.50.

Abiraterone acetate reducing impurity and preparation method thereof

The invention discloses an abiraterone acetate reducing impurity and a preparation method thereof. The impurity is 17-(3-pyridyl) androstane-3 beta-acetoxyl. The preparation method of the impurity includes the steps: taking dehydroepiandrosterone as a starting material; performing catalytic hydrogenation by palladium carbon to obtain (3 beta)-3-hydroxy-17-sterone; performing reaction by hydrazine hydrate to obtain 17-hydrazono-androstane-3 beta-alcohol; performing iodine substitution to obtain 17-iodine-androstane-3 beta-alcohol; reacting the 17-iodine-androstane-3 beta-alcohol with borane reagents under palladium catalysis to obtain 17-(3-pyridyl) androstane-3 beta-alcohol; performing acetic anhydride acetylation to obtain the abiraterone acetate reducing impurity 17-(3-pyridyl) androstane-3 beta-acetoxyl.

Stille and Suzuki Cross-Coupling Reactions as Versatile Tools for Modifications at C-17 of Steroidal Skeletons – A Comprehensive Study

Herein, we report on a comparative Stille and Suzuki cross-coupling study of steroidal vinyl (pseudo)halides with different boronic acids and tributyltin organyls. Furthermore, we have investigated the “inverse” case of those cross-coupling reactions, i.e., the reaction of a steroidal vinylpinacolatoborane or a tributyltin steroid with various bromides. The development of both methods allows the introduction of different residues at C-17 of steroid skeletons providing access to a broad variety of steroid analogues which are of high interest for biological screenings or natural product synthesis. (Figure presented.).

Microbiological hydroxylation of some epoxy steroids by the fungus Mucor plumbeus

The preparation of epoxy steroids derived from testosterone, dehydroisoandrosterone and epiandrosterone using m-chloroperbenzoic acid and their biotransformation by the fungus Mucor plumbeus is described. The results reveal an effect of the epoxide on the biotransformation.