950503-74-9Relevant academic research and scientific papers
From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonists
Alcaraz, Lilian,Bailey, Andrew,Cadogan, Elaine,Connolly, Stephen,Jewell, Robert,Jordan, Stephen,Kindon, Nicholas,Lister, Andrew,Lawson, Mandy,Mullen, Alexander,Dainty, Ian,Nicholls, David,Paine, Stuart,Pairaudeau, Garry,Stocks, Michael J.,Thorne, Phillip,Young, Alan
, p. 689 - 695 (2012/03/26)
Libraries of dibasic compounds designed around the molecular scaffold of the DA2/β2 dual agonist sibenadet (Viozan) have yielded a number of promising starting points that have been further optimised into novel potent and selective target molecules with required pharmacokinetic properties. From a shortlist, 31 was discovered as a novel, high potency, and highly efficacious β2-agonist with high selectivity and a duration of action commensurable with once daily dosing.
