950509-61-2

Basic information

• Product Name: [(R)-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-trityl-amine
• Synonyms: [(R)-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-trityl-amine
• CAS NO: 950509-61-2
• Molecular Weight: 486.58
• Mol File: 950509-61-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [(R)-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-trityl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [(R)-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-trityl-amine(950509-61-2)
• EPA Substance Registry System: [(R)-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-trityl-amine(950509-61-2)

Safety Data

• Hazardous Substances Data: 950509-61-2(Hazardous Substances Data)

Upstream product

• 137036-55-6 (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one 
• 950509-59-8 (R)-3-tritylamino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 950509-60-1 (R)-1-(2,2,2-trifluoro-ethyl)-3-(tritylamino)-1,3,4,5-tetrahydro-1-benzazepin-2-one 
• 76-83-5 trityl chloride 

Downstream Products

• 950509-64-5 tert-butyl (R)-1-oxo-3-phenyl-1-((R)-1-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)propan-2-ylcarbamate 

Relevant articles and documents

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

A series of benzodiazepines and benzazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of the benzazepinone series, compound 47, displayed potent, state-dependent block of hNav1.7, and was orally efficacious in a rat model of neuropathic pain.