950523-96-3Relevant academic research and scientific papers
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors
Pfefferkorn, Jeffrey A.,Choi, Chulho,Song, Yuntao,Trivedi, Bharat K.,Larsen, Scott D.,Askew, Valerie,Dillon, Lisa,Hanselman, Jeffrey C.,Lin, Zhiwu,Lu, Gina,Robertson, Andrew,Sekerke, Catherine,Auerbach, Bruce,Pavlovsky, Alexander,Harris, Melissa S.,Bainbridge, Graeme,Caspers, Nicole
, p. 4531 - 4537 (2008/02/12)
Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in vivo models and may
FUSED BICYCLIC PYRROLS AS HMG-COA REDUCTASE INHIBITORS
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Page/Page column 39, (2010/11/08)
HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidenuc compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.
