950581-51-8Relevant academic research and scientific papers
Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
Kumamoto, Hiroki,Topalis, Dimitri,Broggi, Julie,Pradère, Ugo,Roy, Vincent,Berteina-Raboin, Sabine,Nolan, Steven P.,Deville-Bonne, Dominique,Andrei, Graciela,Snoeck, Robert,Garin, Daniel,Crance, Jean-Marc,Agrofoglio, Luigi A.
, p. 3517 - 3526 (2008/09/21)
In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity.
