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Upstream product

• 573768-09-9 4-amino-2-chloro-3-methyl-benzonitrile 
• 850003-05-3 (2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester 
• 757247-71-5 tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate 
• 757247-74-8 (2R,3S)-N-tert-Butyloxycarbonyl-3-(tert-butyldimethylsilanyloxy)-2-((1S)-1-aminoethyl)-pyrrolidine 
• 757247-76-0 (2R,3S)-1-tert-Butyloxycarbonyl-3-(tert-Butyldimethylsilanyloxy)-2-[(1S)-1-(3-chloro-4-cyano-2-methyl-phenylamino)-ethyl]pyrrolidine 
• 757247-77-1 4-((S)-1-((2R,3S)-3-(tert-butyldimethylsilanyloxy)pyrrolidin-2-yl)ethylamino)-2-chloro-3-methylbenzonitrile 
• 757247-75-9 2-chloro-4-iodo-3-methylbenzonitrile 
• 864271-14-7 (2R,3S)-N-tert-Butyloxycarbonyl-3-(tert-butyldimethylsilanyloxy)-2-(1-hydroxyethyl)-pyrrolidine 
• 757247-72-6 (2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilanyloxy)-2-(1-hydroxyethyl)-pyrrolidine 
• 757247-73-7 C₁₇H₃₄N₂O₄Si 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 156129-73-6 tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 184046-78-4 (2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

Replacement of the 3-oxo group of 2-chloro-4-[(7R,7aS)-7-hydroxy-1,3-dioxotetrahydro-1H-pyrrolo[1,2c]imidazol-2(3H)-yl]-3-methylbenzonitrile resulted in a sulfamide series of selective androgen receptor modulator (SARM) agonists.