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(S)-4-Carbamoyl-2-(4-methylamino-benzoylamino)-butyric acid tert-butyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 95064-03-2 Structure
  • Basic information

    1. Product Name: (S)-4-Carbamoyl-2-(4-methylamino-benzoylamino)-butyric acid tert-butyl ester
    2. Synonyms:
    3. CAS NO:95064-03-2
    4. Molecular Formula:
    5. Molecular Weight: 335.403
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 95064-03-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-4-Carbamoyl-2-(4-methylamino-benzoylamino)-butyric acid tert-butyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-4-Carbamoyl-2-(4-methylamino-benzoylamino)-butyric acid tert-butyl ester(95064-03-2)
    11. EPA Substance Registry System: (S)-4-Carbamoyl-2-(4-methylamino-benzoylamino)-butyric acid tert-butyl ester(95064-03-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 95064-03-2(Hazardous Substances Data)

95064-03-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 95064-03-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,0,6 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 95064-03:
(7*9)+(6*5)+(5*0)+(4*6)+(3*4)+(2*0)+(1*3)=132
132 % 10 = 2
So 95064-03-2 is a valid CAS Registry Number.

95064-03-2Relevant articles and documents

Synthesis of Monoamides of Methotrexate from L-Glutamic Acid Monoamide t-Butyl Esters

Antonjuk, David J.,Boadle, Deborah K.,Cheung, H.T.Andrew,Tran, Trung Q.

, p. 1989 - 2004 (2007/10/02)

Analoques of methotrexate (amethopterin) (1) with α- or γ-monoamide functions were synthesized starting with t-butyl L-isoglutamine (12a), t-butyl L-glutamine (22a), or the appropriate N'-alkyl or N'N'-dialkyl analoques (12b-k), (22d), (22k), (22l), and (22m).The corresponding N-benzyloxycarbonyl compounds (11) and/or (21) from which the above L-glutamic acid derivatives were obtained were generally synthesized by mixed-anhydride coupling of N-benzyloxycarbonyl-L-glutamic acid (9) with the appropriate amine, conversion into the t-butyl ester, and chromatographic separation.The resulting α-monoamide γ-t-butyl ester (11) and γ-monoamide α-t-butyl ester (21) are unambiguously distinguished by mass spectrometry and 13C n.m.r. spectroscopy.Factors which affect the γ-amide/α-amide product ratio are discussed.The N-deprotected L-glutamic acid monoamide t-butyl esters (12) or (22) were individually coupled to N-trifluoroacetyl-p-methylaminobenzoic acid, and the resulting α- or γ-monoamide t-butyl esters (13) or (23) of N-(p-methyl(trifluoroacetyl)aminobenzoyl)-L-glutamic acid was hydrolysed.The N-deprotected product, viz. t-butyl N-(p-methylaminobenzoyl)-L-glutamate α- or γ-monoamide (14) or (24) was converted into the appropriate methotrexate-monoamide t-butyl ester (15) or (25), and thence the desired methotrexate-monoamide (16) or (26), by reaction with 2,4-diamino-6-bromomethylpteridine (17) or by the Taylor procedure.Features of the mass and 13C n.m.r. spectra of the intermediates are discussed.

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