95064-66-7Relevant academic research and scientific papers
Synthesis of 2,4-Dioxo-,2-Oxo-4-thio-,4-Oxo-, and 4-Thioxo-pyrimidine-5-carbonitriles
Cuadrado, Francisco J.,Perez, Miguel A.,Soto, Jose L.
, p. 2447 - 2450 (2007/10/02)
Methyl N-methoxycarbonylimidates (1)-(4) cyclized readily with 2-cyanoacetamide (5) or 2-cyanoethanethioamide (6) to 2,4-dioxopyrimidine-5-carbonitriles (7)-(10) or 2-oxo-4-thioxopyrimidine-5-carbonitriles (11) and (12).In analogous reactions with alkyl N-acylimidates (15)-(19) 4-oxopyrimidine-5-carbonitriles (20)-(23) or 4-thioxopyrimidine-5-carbonitrile (24) were obtained.Representatives of 4-thioxopyrimidine-5-carbonitriles (11), (24) were methylated to 4-methylthiopyrimidine-5-carbonitriles (13) and (25) or cyclized with methyl chloroacetate to give methyl thienopyrimidine-6-carboxylates (14) and (26)
