950673-89-9Relevant academic research and scientific papers
Chromanol derivatives - A novel class of CETP inhibitors
Vakalopoulos, Alexandros,Schmeck, Carsten,Thutewohl, Michael,Li, Volkhart,Bischoff, Hilmar,Lustig, Klemens,Weber, Olaf,Paulsen, Holger,Elias, Harry
scheme or table, p. 488 - 491 (2011/02/27)
Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties suitable for clinical studies. Chemical process optimization furnished a robust synthesis for a kilogram-scale process.
Substituted Chromanol Derivatives and Their Use
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Page/Page column 49; 50, (2009/12/24)
The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatmen
