95069-00-4Relevant academic research and scientific papers
THE SYNTHESIS OF OPTICALLY PURE β-LACTAMS DERIVED FROM SUGARS. HIGH-PRESSURE CYCLOADDITION OF TOLUENE-4-SULPHONYL ISOCYANATE TO GLYCALS.
Chmielewski, M.,Kaluza, Z.,Belzecki, C.,Salanski, P.,Jurczak, J.
, p. 4797 - 4800 (2007/10/02)
Cycloaddition of toluene-4-sulphonyl isocyanate to glycals 1-4 at room temperature under 10 kbar pressure gave respective β-lactams 5-8 in good yields.The reaction proceeds regio- and stereospecifically to afford the four-membered ring in position trans to the acetoxy group at C-3 of the glycal moiety.
