950694-19-6

Upstream product

• 329779-41-1 α-(3-chloro-4-fluoroaniline)-2-cresol 

Downstream Products

• 950694-21-0 [3-(3-chloro-4-fluorophenyl)-2-oxo-3,4-dihydro-2H-2λ⁵-benzo[e][1,3,2]oxazaphosphinin-2-yl]-4-chlorophenylmethanol 
• 950694-27-6 [3-(3-chloro-4-fluorophenyl)-2-oxo-3,4-dihydro-2H-2λ⁵-benzo[e][1,3,2]oxazaphosphinin-2-yl]-3-nitrophenylmethanol 
• 950694-29-8 [3-(3-chloro-4-fluorophenyl)-2-oxo-3,4-dihydro-2H-2λ⁵-benzo[e][1,3,2]oxazaphosphinin-2-yl]-3-phenyl-2-propen-1-ol 
• 950694-30-1 [3-(3-chloro-4-fluorophenyl)-2-oxo-3,4-dihydro-2H-2λ⁵-benzo[e][1,3,2]oxazaphosphinin-2-yl]-but-2-en-1-ol 

Relevant academic research and scientific papers

Synthesis and anticancer activity of new class of bisphosphonates/phosphanamidates

Novel bis-heterocyclic bisphosphonates/phosphonamidates were synthesized utilizing the Pudovick reaction. The employment of Nb2O5 as catalyst was found to increase the yields and purity of the bisbenzoxazaphosphine derivatives (13a-h). Their anticancer activity studies in vitro, on three human tumor cell lines NCI-H460 (lung large cell), MCF-7 (breast adenocarcinoma), and SF-268 (central nervous system glioblastoma), showed that bis-[3-(3-chloro-4-fluorophenyl)-2-oxo-3,4-dihydro-2H-2λ5-benzo[e][1,3,2]oxazaphosphinin-2-yl]arylmethanes (13a-h) and [(4-chlorophenyl)-(hydroxyamidophosphinoyl)-methyl]phosphonic acid (14) exhibited significant anticancer activity.